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可穿戴生物传感器为个人健康检测提供了新途径,汗液检测因样本易采集、可连续监测等优势备受关注。金属有机框架(MOF)作为新兴材料,在汗液检测领域展现出独特潜力。本文综述了可穿戴电化学生物传感器用于汗液检测的研究进展,详细介绍了生物酶、生物抗体、分子印迹聚合物、金属纳米材料等常见敏感材料及其检测原理,总结了汗液中生物标志物的浓度范围;深入探讨了MOF用于汗液检测的优势与缺点以及常见制备方法,阐述了基于MOF的汗液传感器对葡萄糖、乳酸、皮质醇等生物标志物的检测应用;最后,对MOF基可穿戴汗液传感器的发展进行了展望。
Abstract:Wearable biosensors provide a new approach for personal health monitoring.Sweat detection has drawn significant attention due to advantages such as easy sample collection and continuous monitoring.As an emerging material, metal-organic frameworks(MOFs) demonstrate unique potential in the field of sweat detection.This paper reviews the research progress of wearable electrochemical biosensors for sweat detection, elaborately introduces common sensitive materials like bioenzymes, bioantibodies, molecularly imprinted polymers, and metal nanomaterials, along with their detection principles, and summarizes the concentration ranges of biomarkers in sweat.It deeply explores the advantages and disadvantages of MOFs used in sweat detection, as well as common preparation methods, and expounds on the detection applications of MOF-based sweat sensors for biomarkers such as glucose, lactate, and cortisol.Finally, prospects for the development of MOF-based wearable sweat sensors are presented.
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基本信息:
DOI:10.20062/j.cnki.CN37-1453/N.2025.03.001
中图分类号:O657.1;TP212;O641.4
引用信息:
[1]董文豪,陈雪叶.金属有机框架(MOF)可穿戴电化学汗液传感器的研究进展[J].鲁东大学学报(自然科学版),2025,41(03):193-208.DOI:10.20062/j.cnki.CN37-1453/N.2025.03.001.
基金信息:
山东省泰山学者青年专家计划(tsqn202103091); 山东省自然科学基金(ZR2024ME052); 烟台市科技创新发展计划重点基础研究项目(2023JCYJ048); 烟台市省级以上领军人才专项扶持资金(220-20230002); 鲁东大学引进人才启动项目(LD22065)