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2、6及8位完全为氢原子的嘌呤衍生物是一类具有重要合成转化价值的关键有机中间体，然而由于其结构上相似的化学环境导致2、6及8位CH的核磁信号归属难以区分，目前相关研究较少。鉴于此，利用~1H NMR、13C NMR、2D NMR(HSQC、HMBC)技术，系统分析在不同溶剂及取代基存在情况下，2,6,8-三氢嘌呤衍生物核磁共振谱图上化学位移的归属及变化规律。结果显示：氢谱上，6位氢的化学位移最大，其次是2位氢，最小的是8位氢；碳谱的化学位移则是2位最大，其次是6位，最小的是8位。该研究为2,6,8-三氢嘌呤衍生物合成及进一步衍生化修饰提供了参考依据。
Abstract：The purine derivatives with 2,6 and 8 positions fully substituted by hydrogen atoms are a class of key intermediates with synthetic transformation.Due to the similar chemical environments in their structures, it is difficult to distinguish the NMR signals of the C—H at the 2,6,and 8 positions, and there is currently no systematic research.In view of this, we use ~1H NMR,13C NMR,2D NMR(HSQC,HMBC) experiments to systematically analyze the chemical shift assignments and changes in the NMR of 2,6,8-trihydroxy purine derivatives with different substituents in different solvents.The results show that in the spectrum, the chemical shift of the hydrogen at the C6—H position is the largest, followed by the hydrogen at the C2—H position, and the smallest is the hydrogen at the C8—H position.In the carbon spectrum, the chemical shift is the largest at C2-position, followed by C6-position, and the smallest at C8-position.The result provides valuable guidance for the synthesis and further derivatization modification of 2,6,8-trihydroxy purine derivatives.
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基本信息:
DOI：10.20062/j.cnki.CN37-1453/N.2026.01.009
中图分类号:O626;O657.61
引用信息:
[1]蒋中凯,刘刚,包昕,等.2,6,8-三氢嘌呤衍生物的核磁共振波谱研究[J].鲁东大学学报(自然科学版),2026,42(01):80-87.DOI:10.20062/j.cnki.CN37-1453/N.2026.01.009.
基金信息:
山东省自然科学基金(ZR2019BB043)